HORDB

ID: hor003520
Uniprot ID: Q9NL83
Protein name: Orcomyotropin-like peptide
Gene name: NA
Organism: Procambarus clarkii (Red swamp crayfish)
Family: Orcokinin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Procambarus (genus), Cambarinae (subfamily), Cambaridae (family), Astacoidea (superfamily), Astacidea (infraorder), Pleocyemata (suborder), Decapoda (order), Eucarida (superorder), Eumalacostraca (subclass), Malacostraca (class), Multicrustacea (superclass), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005184 neuropeptide hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: FDAFTTGFGHS
Length: 11
Propeptide: MTAQMFTIALLLSLSAIAAAGTIKTAPARTPSTQDDASFPPDGAPVKRFDAFTTGFGHSKRNFDEIDRSGFGFAKKNFDEIDRSGFGFNKRNFDEIDRSGFGFNKRNFDEIDRSGFGFNKRNFDEIDRSGFGFNKRNFDEIDRSGFGFNKRNFDEIDRSGFGFNKRNFDEIDRSGFGFVKRVYVPRYIANLYKRNFDEIDRSGFGFNKRNFDEIDRTGFGFHKRDYDVFPDKRNFDEIDRSGFGFVRRNVE
Signal peptide: MTAQMFTIALLLSLSAIAAA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Myotropic peptides that enhance both the frequency and amplitude of spontaneous hindgut contractions
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor003520_AF2.pdb

hor003520_ESM.pdb

Mass:	136479	Formula:	C55H71N13O17
Absent amino acids:	CEIKLMNPQRVWY	Common amino acids:	F
pI:	5.29	Basic residues:	1
Polar residues:	5	Hydrophobic residues:	4
Hydrophobicity:	4.55	Boman Index:	-929
Half-Life:	1.1 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	2 min	Aliphatic Index	9.09
Instability Index:	1259.09	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 10753578
Title: Identification of Orcokinin Gene-Related Peptides in the Brain of the Crayfish Procambarus Clarkii by the Combination of MALDI-TOF and On-Line Capillary HPLC/Q-Tof Mass Spectrometries and Molecular Cloning